Cytotoxic Therapy–Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms

Therapy-related myeloid neoplasms (t-MN) following treatment with alkylating agents are characterized by a del(5q), complex karyotypes, alterations of TP53, and a dismal prognosis. To decipher the molecular pathway(s) leading to the pathogenesis of del(5q) t-MN and the effect(s) of cytotoxic therapy...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Stoddart, Angela, Wang, Jianghong, Fernald, Anthony A., Davis, Elizabeth M., Johnson, Camille R., Hu, Chunmei, Cheng, Jason X., McNerney, Megan E., Le Beau, Michelle M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486063/
https://ncbi.nlm.nih.gov/pubmed/32924016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-19-0028
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