Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans

Transmission to chimpanzees of a precore hepatitis B virus (HBV) mutant implicated in acute liver failure (ALF) in humans did not cause ALF nor the classic form of acute hepatitis B (AHB) seen upon infection with the wild-type HBV strain, but rather a severe AHB with distinct disease features. Here,...

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Pubblicato in:PLoS Pathog
Autori principali: Chen, Zhaochun, Engle, Ronald E., Shen, Chen-Hsiang, Zhao, Huaying, Schuck, Peter W., Danoff, Emily J., Nguyen, Hanh, Nishimura, Norihisa, Bock, Kevin W., Moore, Ian N., Kwong, Peter D., Purcell, Robert H., Govindarajan, Sugantha, Farci, Patrizia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485984/
https://ncbi.nlm.nih.gov/pubmed/32866189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008793
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