Acute and Chronic Vascular Effects of Inhaled Crotonaldehyde in Mice: Role of TRPA1

Although crotonaldehyde (CR) is an abundant α,β-unsaturated aldehyde in mainstream cigarette smoke (MCS), the cardiovascular toxicity of inhaled CR is largely unexplored. Thus, male C57BL/6J mice were exposed acutely (1h, 6h, and 4d) and chronically (12 weeks) to CR (at levels relevant to MCS; 1 and...

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Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Lynch, Jordan, Jin, Lexiao, Richardson, Andre, Jagatheesan, Ganapathy, Lorkiewicz, Pawel, Xie, Zhengzhi, Theis, Whitney S., Shirk, Gregg, Malovichko, Marina, Bhatnagar, Aruni, Srivastava, Sanjay, Conklin, Daniel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485374/
https://ncbi.nlm.nih.gov/pubmed/32634517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115120
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