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Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase-3 Activation: A Study With the Kinase Inhibitor Staurosporine

Oxidative stress is known to contribute to the progression of apoptosis. Staurosporine is a broad-spectrum inducer of apoptosis, but its mechanism of action is not well understood. The goal of the present work was to elucidate the role of glutathione and reactive oxygen species (ROS) in the executio...

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發表在:Front Physiol
Main Authors: Musaogullari, Aysenur, Mandato, Alysia, Chai, Yuh-Cherng
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485172/
https://ncbi.nlm.nih.gov/pubmed/32982774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00998
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