Induction of natural killer antibody-dependent cell cytotoxicity and of clinical activity of cetuximab plus avelumab in non-small cell lung cancer

BACKGROUND: Antibody-dependent cell-mediated cytotoxicity (ADCC) may mediate antitumour activity of IgG1-isotype monoclonal antibody (mAb), suggesting as potential treatment combination of IgG1-mAbs, anti-epidermal growth factor receptor cetuximab and anti-programmed death-ligand-1 avelumab. METHODS...

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Veröffentlicht in:ESMO Open
Hauptverfasser: Fasano, Morena, Della Corte, Carminia Maria, Di Liello, Raimondo, Barra, Giusi, Sparano, Francesca, Viscardi, Giuseppe, Iacovino, Maria Lucia, Paragliola, Fernando, Famiglietti, Vincenzo, Ciaramella, Vincenza, Cimmino, Flora, Capasso, Mario, Iolascon, Achille, Sforza, Vincenzo, Morabito, Alessandro, Maiello, Evaristo, Ciardiello, Fortunato, Morgillo, Floriana
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484864/
https://ncbi.nlm.nih.gov/pubmed/32912860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2020-000753
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