Rac1 conditional deletion attenuates retinal ganglion cell apoptosis by accelerating autophagic flux in a mouse model of chronic ocular hypertension

Autophagy has a fundamental role in maintaining cell homeostasis. Although autophagy has been implicated in glaucomatous pathology, how it regulates retinal ganglion cell (RGC) injury is largely unknown. In the present work, we found that biphasic autophagy in RGCs occurred in a mouse model of chron...

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Vydáno v:Cell Death Dis
Hlavní autoři: Zhang, Meng-Lu, Zhao, Guo-Li, Hou, Yu, Zhong, Shu-Min, Xu, Lin-Jie, Li, Fang, Niu, Wei-Ran, Yuan, Fei, Yang, Xiong-Li, Wang, Zhongfeng, Miao, Yanying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484783/
https://ncbi.nlm.nih.gov/pubmed/32913260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02951-7
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