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Alkaline Phosphatase Activity Is A Key Determinant of Vascular Responsiveness to Norepinephrine
Here we tested the hypothesis that tissue non-specific alkaline phosphatase (TNAP) modulates vascular responsiveness to norepinephrine. In the isolated, Tyrode’s-perfused rat mesentery, 50 μmol/L of L-p-bromotetramisole (selective TNAP inhibitor, K(i)=56 μmol/L) significantly reduced TNAP activity a...
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| Publicado no: | Hypertension |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484402/ https://ncbi.nlm.nih.gov/pubmed/32829665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15822 |
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