MAPPING THE EFFECTS OF GENETIC VARIATION ON CHROMATIN STATE AND GENE EXPRESSION REVEALS LOCI THAT CONTROL GROUND STATE PLURIPOTENCY

Mouse embryonic stem cells (mESCs) cultured in the presence of LIF occupy a ground state with highly active pluripotency-associated transcriptional and epigenetic circuitry. However, ground state pluripotency in some inbred strain backgrounds is unstable in the absence of ERK1/2 and GSK3 inhibition....

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Publicat a:Cell Stem Cell
Autors principals: Skelly, Daniel A., Czechanski, Anne, Byers, Candice, Aydin, Selcan, Spruce, Catrina, Olivier, Chris, Choi, Kwangbom, Gatti, Daniel M., Raghupathy, Narayanan, Keele, Gregory R., Stanton, Alexander, Vincent, Matthew, Dion, Stephanie, Greenstein, Ian, Pankratz, Matthew, Porter, Devin K., Martin, Whitney, O’Connor, Callan, Qin, Wenning, Harrill, Alison H., Choi, Ted, Churchill, Gary A., Munger, Steven C., Baker, Christopher L., Reinholdt, Laura G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484384/
https://ncbi.nlm.nih.gov/pubmed/32795400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.07.005
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