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Real-time Characterization of Cell Membrane Disruption by α-Synuclein Oligomers in Live SH-SY5Y Neuroblastoma Cells

Aggregation of the natively unfolded protein α-synuclein (α-Syn) has been widely correlated to the neuronal death associated with Parkinson’s disease. Mutations and protein overaccumulation can promote the aggregation of α-Syn into oligomers and fibrils. Recent work has suggested that α-Syn oligomer...

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Bibliografske podrobnosti
izdano v:ACS Chem Neurosci
Main Authors: Parres-Gold, Jacob, Chieng, Andy, Su, Stephanie Wong, Wang, Yixian
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484231/
https://ncbi.nlm.nih.gov/pubmed/32786327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00309
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