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Extended Release Pellets Prepared by Hot Melt Extrusion Technique for Abuse Deterrent Potential: Category-1 In-vitro Evaluation

The objective of the present study was to develop extended-release (ER) hot-melt extruded (HME) abuse-deterrent pellets of acetaminophen, a model drug, by utilizing high molecular weight polyethylene oxide (PEO) and gelling agents (xanthan gum, guar gum, and gellan gum). The HME pellets were evaluat...

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Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Butreddy, Arun, Sarabu, Sandeep, Dumpa, Nagireddy, Bandari, Suresh, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484191/
https://ncbi.nlm.nih.gov/pubmed/32653597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2020.119624
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