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Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase

Most terpene synthase reactions follow Markovnikov rules for formation of high energy carbenium ion intermediates. However, there are notable exceptions. For example, pentalenene synthase (PS) undergoes an initial anti-Markovnikov cyclization reaction followed by a 1,2-hydride shift to form an inter...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Matos, Jason O., Kumar, Ramasamy P., Ma, Alison C., Patterson, MacKenzie, Krauss, Isaac J., Oprian, Daniel D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484107/
https://ncbi.nlm.nih.gov/pubmed/32786410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00518
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