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Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues

The stereochemical course of monoterpene synthase reactions is thought to be determined early in the reaction sequence by selective binding of distinct conformations of the geranyl diphosphate (GPP) substrate. We explore here formation of early Michaelis complexes of the (+)-limonene synthase [(+)-L...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Kumar, Ramasamy P., Morehouse, Benjamin R., Matos, Jason O., Malik, Karan, Lin, Hongkun, Krauss, Isaac J., Oprian, Daniel D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642273/
https://ncbi.nlm.nih.gov/pubmed/28272876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00144
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