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Membrane insertion exacerbates the α-Synuclein-Cu(II) dopamine oxidase activity: metallothionein-3 targets and silences all α-Synuclein-Cu(II) complexes
Copper binding to α-synuclein (α-Syn), the major component of intracellular Lewy body inclusions in substantia nigra dopaminergic neurons, potentiate its toxic redox-reactivity and plays a detrimental role in the etiology of Parkinson disease (PD). Soluble α-synuclein-Cu(II) complexes possess dopami...
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| Udgivet i: | Free Radic Biol Med |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484060/ https://ncbi.nlm.nih.gov/pubmed/32712192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.07.006 |
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