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Conformational basis of G protein-coupled receptor signaling versatility

G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands exhibit significant “bias”—the ability to preferentially activate subsets of the many cellular pathways downstrea...

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Publicat a:Trends Cell Biol
Autors principals: Wingler, Laura M., Lefkowitz, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483927/
https://ncbi.nlm.nih.gov/pubmed/32622699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2020.06.002
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