Anti-PD-1 induces M1 polarization in the glioma microenvironment and exerts therapeutic efficacy in the absence of CD8 cytotoxic T cells

PURPOSE: Anti-programmed cell death protein 1 (PD-1) therapy has demonstrated inconsistent therapeutic results in patients with glioblastoma (GBM) including those with profound impairments in CD8 T cell effector responses. We sought to determine the EXPERIMENTAL DESIGN: We ablated the CD8alpha gene...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Rao, Ganesh, Latha, Khatri, Ott, Martina, Sabbagh, Aria, Marisetty, Anantha, Ling, Xiaoyang, Zamler, Daniel, Doucette, Tiffany A., Yang, Yuhui, Kong, Ling-Yuan, Wei, Jun, Fuller, Gregory N., Benavides, Fernando, Sonabend, Adam M., Long, James, Li, Shulin, Curran, Michael, Heimberger, Amy B.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483850/
https://ncbi.nlm.nih.gov/pubmed/32554515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-4110
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires