Interleukin-4 overexpressing mesenchymal stem cells within gelatin-based microribbon hydrogels enhance bone healing in a murine long bone critical-size defect model

Mesenchymal stem cell (MSC)-based therapy is a promising strategy for bone repair. Furthermore, the innate immune system, and specifically macrophages, plays a crucial role in the differentiation and activation of MSCs. The anti-inflammatory cytokine Interleukin-4 (IL-4) converts pro-inflammatory M1...

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Udgivet i:J Biomed Mater Res A
Main Authors: Ueno, Masaya, Lo, Chi-Wen, Barati, Danial, Conrad, Bogdan, Lin, Tzuhua, Kohno, Yusuke, Utsunomiya, Takeshi, Zhang, Ning, Maruyama, Masahiro, Rhee, Claire, Huang, Ejun, Romero-Lopez, Monica, Tong, Xinming, Yao, Zhenyu, Zwingenberger, Stefan, Yang, Fan, Goodman, Stuart B.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483618/
https://ncbi.nlm.nih.gov/pubmed/32363683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.36982
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