Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent models of neurological diseases and substance use disorders. However, the mechanism behind GLT-1 upregulation is unknown....

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Bibliographic Details
Published in:Neurosci Biobehav Rev
Main Authors: Smaga, Irena, Fierro, Daniel, Mesa, Javier, Filip, Malgorzata, Knackstedt, Lori A
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483567/
https://ncbi.nlm.nih.gov/pubmed/32485268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neubiorev.2020.05.016
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