Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli

Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models (GEMs) to explore the effect of coinfection of the diarrheagenic pathogen Vibrio cholerae with a...

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Detalhes bibliográficos
Publicado no:mSystems
Main Authors: Abdel-Haleem, Alyaa M., Ravikumar, Vaishnavi, Ji, Boyang, Mineta, Katsuhiko, Gao, Xin, Nielsen, Jens, Gojobori, Takashi, Mijakovic, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483508/
https://ncbi.nlm.nih.gov/pubmed/32900868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00491-20
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