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Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli

Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models (GEMs) to explore the effect of coinfection of the diarrheagenic pathogen Vibrio cholerae with a...

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Bibliografiske detaljer
Udgivet i:mSystems
Main Authors: Abdel-Haleem, Alyaa M., Ravikumar, Vaishnavi, Ji, Boyang, Mineta, Katsuhiko, Gao, Xin, Nielsen, Jens, Gojobori, Takashi, Mijakovic, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483508/
https://ncbi.nlm.nih.gov/pubmed/32900868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00491-20
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