Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli

Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models (GEMs) to explore the effect of coinfection of the diarrheagenic pathogen Vibrio cholerae with a...

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Pubblicato in:mSystems
Autori principali: Abdel-Haleem, Alyaa M., Ravikumar, Vaishnavi, Ji, Boyang, Mineta, Katsuhiko, Gao, Xin, Nielsen, Jens, Gojobori, Takashi, Mijakovic, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483508/
https://ncbi.nlm.nih.gov/pubmed/32900868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00491-20
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