Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix contains high amounts of Aggrecan and COMP, we hypothes...

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Bibliografiska uppgifter
I publikationen:Front Bioeng Biotechnol
Huvudupphovsmän: Caron, Marjolein M. J., Janssen, Maarten P. F., Peeters, Laura, Haudenschild, Dominik R., Cremers, Andy, Surtel, Don A. M., van Rhijn, Lodewijk W., Emans, Pieter J., Welting, Tim J. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Bioengineering and Biotechnology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483497/
https://ncbi.nlm.nih.gov/pubmed/32984292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.01036
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