Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix contains high amounts of Aggrecan and COMP, we hypothes...

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Vydáno v:Front Bioeng Biotechnol
Hlavní autoři: Caron, Marjolein M. J., Janssen, Maarten P. F., Peeters, Laura, Haudenschild, Dominik R., Cremers, Andy, Surtel, Don A. M., van Rhijn, Lodewijk W., Emans, Pieter J., Welting, Tim J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Bioengineering and Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483497/
https://ncbi.nlm.nih.gov/pubmed/32984292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.01036
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