Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

Splicing alterations are common in disease, such as cancer, where mutations in splicing factor genes are frequently responsible for aberrant splicing. Here we present an alternative mechanism for splicing regulation in T cell acute lymphoblastic leukemia (T-ALL), that involves posttranslational stab...

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Publicado no:Cancer Discov
Main Authors: Zhou, Yalu, Han, Cuijuan, Wang, Eric, Lorch, Adam H., Serafin, Valentina, Cho, Byoung-Kyu, Diaz, Blanca T. Gutierrez, Calvo, Julien, Fang, Celestia, Khodadadi-Jamayran, Alireza, Tabaglio, Tommaso, Marier, Christian, Kuchmiy, Anna, Sun, Limin, Yacu, George, Filip, Szymon K., Jin, Qi, Takahashi, Yoh-hei, Amici, David R., Rendleman, Emily J., Rawat, Radhika, Bresolin, Silvia, Paganin, Maddalena, Zhang, Cheng, Li, Hu, Kandela, Irawati, Politanska, Yuliya, Abdala-Valencia, Hiam, Mendillo, Marc L., Zhu, Ping, Palhais, Bruno, Van Vlierberghe, Pieter, Taghon, Tom, Aifantis, Iannis, Goo, Young Ah, Guccione, Ernesto, Heguy, Adriana, Tsirigos, Aristotelis, Wee, Keng Boon, Mishra, Rama K., Pflumio, Francoise, Accordi, Benedetta, Basso, Giuseppe, Ntziachristos, Panagiotis
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483384/
https://ncbi.nlm.nih.gov/pubmed/32444465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1436
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