Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD(+) Ratio

Aims: Glucose-stimulated insulin secretion (GSIS) in pancreatic β cells was expected to enhance mitochondrial superoxide formation. Hence, we elucidated relevant redox equilibria. Results: Unexpectedly, INS-1E cells at transitions from 3 (11 mM; pancreatic islets from 5 mM) to 25 mM glucose decrease...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Plecitá-Hlavatá, Lydie, Engstová, Hana, Holendová, Blanka, Tauber, Jan, Špaček, Tomáš, Petrásková, Lucie, Křen, Vladimír, Špačková, Jitka, Gotvaldová, Klára, Ježek, Jan, Dlasková, Andrea, Smolková, Katarína, Ježek, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
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Forum Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482716/
https://ncbi.nlm.nih.gov/pubmed/32517485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7800
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