Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1- Deficient Mice

Neurofibromatosis Type 1 (NF1) is one of the most common genetic tumor predisposition syndromes in humans. Mutant NF1 results in dysregulated RAS allowing neoplasms throughout the neuroaxis. Plexiform neurofibromas (pNFs) afflict up to 50% of patients with NF1. They are complex tumors of the periphe...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Burks, Ciersten A., Rhodes, Steven D., Bessler, Waylan K., Chen, Shi, Smith, Abbi, Gehlhausen, Jeffrey R., Hawley, Eric T., Jiang, Li, Li, Xiaohong, Yuan, Jin, Lu, Qingbo, Jacobsen, Max, Sandusky, George, Jones, David R., Clapp, D. Wade, Blakeley, Jaishri
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482139/
https://ncbi.nlm.nih.gov/pubmed/31527226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0123
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