CRISPR base editing and prime editing: DSB and template-free editing systems for bacteria and plants

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated) has been extensively exploited as a genetic tool for genome editing. The RNA guided Cas nucleases generate DNA double-strand break (DSB), triggering cellular repair systems mainly Non-homologous end-joining (NHE...

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發表在:Synth Syst Biotechnol
Main Authors: Abdullah, Jiang, Zhengzheng, Hong, Xulin, Zhang, Shun, Yao, Ruilian, Xiao, Yi
格式: Artigo
語言:Inglês
出版: KeAi Publishing 2020
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Review Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481536/
https://ncbi.nlm.nih.gov/pubmed/32954022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2020.08.003
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