Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

Ectonucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of nucleoside tri- and di-phosphates to mono-phosphates. The products are subsequently hydrolyzed by ecto-5′-nucleotidase (ecto-5′-NT) to nucleosides. NTPDase inhibitors have potential as novel drugs, e.g., for the tr...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Baqi, Younis, Rashed, Mahmoud, Schäkel, Laura, Malik, Enas M., Pelletier, Julie, Sévigny, Jean, Fiene, Amelie, Müller, Christa E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481482/
https://ncbi.nlm.nih.gov/pubmed/32973513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01282
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