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Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss....

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Vydáno v:Front Aging Neurosci
Hlavní autoři: d‘Errico, Paolo, Meyer-Luehmann, Melanie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481386/
https://ncbi.nlm.nih.gov/pubmed/33061903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00265
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