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Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease
Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss....
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| Pubblicato in: | Front Aging Neurosci |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7481386/ https://ncbi.nlm.nih.gov/pubmed/33061903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00265 |
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