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Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism
Neurexins are presynaptic adhesion molecules that organize synapses by binding to diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood. Here we identify FAM19A/TAFA proteins, “orphan" cytokines, as neurexin regulators that interact with all neurexins, excep...
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| Pubblicato in: | J Cell Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Rockefeller University Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7480106/ https://ncbi.nlm.nih.gov/pubmed/32706374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202004164 |
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