Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Ependymoma is a heterogeneous entity of central nervous system tumors with well-established molecular groups. Here, we apply single-cell RNA sequencing to analyze ependymomas across molecular groups and anatomic locations to investigate their intratumoral heterogeneity and developmental origins. Epe...

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Udgivet i:Cancer Cell
Main Authors: Gojo, Johannes, Englinger, Bernhard, Jiang, Li, Hübner, Jens M., Shaw, McKenzie L., Hack, Olivia A., Madlener, Sibylle, Kirchhofer, Dominik, Liu, Ilon, Pyrdol, Jason, Hovestadt, Volker, Mazzola, Emanuele, Mathewson, Nathan D., Trissal, Maria, Lötsch, Daniela, Dorfer, Christian, Haberler, Christine, Halfmann, Angela, Mayr, Lisa, Peyrl, Andreas, Geyeregger, Rene, Schwalm, Benjamin, Mauermann, Monica, Pajtler, Kristian W., Milde, Till, Shore, Marni E., Geduldig, Jack E., Pelton, Kristine, Czech, Thomas, Ashenberg, Orr, Wucherpfennig, Kai W., Rozenblatt-Rosen, Orit, Alexandrescu, Sanda, Ligon, Keith L., Pfister, Stefan M., Regev, Aviv, Slavc, Irene, Berger, Walter, Suvà, Mario L., Kool, Marcel, Filbin, Mariella G.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479515/
https://ncbi.nlm.nih.gov/pubmed/32663469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.004
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