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A perspective on HPK1 as a novel immuno-oncology drug target

In this perspective review, the role Hematopoietic Progenitor Kinase 1 (HPK1) in tumor immunity will be reviewed, with special emphasis on how T cells are negatively-regulated at different junctures of cancer-immunity cycle by this regulatory kinase. The review will highlight the strengths and weakn...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sawasdikosol, Sansana, Burakoff, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478889/
https://ncbi.nlm.nih.gov/pubmed/32896273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55122
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