Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis

Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood. Here, we show that podocyte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucially controls disease in murine models of adria...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Angeletti, Andrea, Cantarelli, Chiara, Petrosyan, Astgik, Andrighetto, Sofia, Budge, Kelly, D’Agati, Vivette D., Hartzell, Susan, Malvi, Deborah, Donadei, Chiara, Thurman, Joshua M., Galešić-Ljubanović, Danica, He, John Cijiang, Xiao, Wenzhen, Campbell, Kirk N., Wong, Jenny, Fischman, Clara, Manrique, Joaquin, Zaza, Gianluigi, Fiaccadori, Enrico, La Manna, Gaetano, Fribourg, Miguel, Leventhal, Jeremy, Da Sacco, Stefano, Perin, Laura, Heeger, Peter S., Cravedi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478737/
https://ncbi.nlm.nih.gov/pubmed/32717081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191699
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