Erythropoietin inhibits SGK1-dependent Th17 cell induction and Th17 cell–dependent kidney disease

IL-17–producing CD4(+) (Th17) cells are pathogenically linked to autoimmunity and, specifically, to autoimmune kidney disease. The newly recognized immunoregulatory functions of erythropoietin (EPO) and its predominant intrarenal source suggested that EPO physiologically regulates Th17 cell differen...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Donadei, Chiara, Angeletti, Andrea, Cantarelli, Chiara, D’Agati, Vivette D., La Manna, Gaetano, Fiaccadori, Enrico, Horwitz, Julian K., Xiong, Huabao, Guglielmo, Chiara, Hartzell, Susan, Madsen, Joren C., Maggiore, Umberto, Heeger, Peter S., Cravedi, Paolo
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542617/
https://ncbi.nlm.nih.gov/pubmed/31013255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127428
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