Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases

Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis (RA), and osteoarthritis (OA) both in humans and in animal models, drives pain associated with these diseases. We foun...

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Publicat a:J Exp Med
Autors principals: Mailhot, Benoit, Christin, Marine, Tessandier, Nicolas, Sotoudeh, Chaudy, Bretheau, Floriane, Turmel, Roxanne, Pellerin, Ève, Wang, Feng, Bories, Cyril, Joly-Beauparlant, Charles, De Koninck, Yves, Droit, Arnaud, Cicchetti, Francesca, Scherrer, Grégory, Boilard, Eric, Sharif-Naeini, Reza, Lacroix, Steve
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478735/
https://ncbi.nlm.nih.gov/pubmed/32573694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191430
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