Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer’s disease (AD) risk. In mouse models of amyloid β (Aβ) accumulation, defective TREM2 function affects microglial response to Aβ plaques, exacerbating tissue damage, w...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: Wang, Shoutang, Mustafa, Meer, Yuede, Carla M., Salazar, Santiago Viveros, Kong, Philip, Long, Hua, Ward, Michael, Siddiqui, Omer, Paul, Robert, Gilfillan, Susan, Ibrahim, Adiljan, Rhinn, Hervé, Tassi, Ilaria, Rosenthal, Arnon, Schwabe, Tina, Colonna, Marco
フォーマット: Artigo
言語:Inglês
出版事項: Rockefeller University Press 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478730/
https://ncbi.nlm.nih.gov/pubmed/32579671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200785
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