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Prediction of an MMP-1 inhibitor activity cliff using the SAR matrix approach and its experimental validation
A matrix metalloproteinase 1 (MMP-1) inhibitor activity cliff was predicted using the SAR Matrix method. Compound 4 was predicted as a highly potent activity cliff partner and found to possess 60 times higher inhibitory activity against MMP-1 than the structurally related compound 3. Furthermore, ph...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7477548/ https://ncbi.nlm.nih.gov/pubmed/32895466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71696-2 |
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