Loading...
Prediction of an MMP-1 inhibitor activity cliff using the SAR matrix approach and its experimental validation
A matrix metalloproteinase 1 (MMP-1) inhibitor activity cliff was predicted using the SAR Matrix method. Compound 4 was predicted as a highly potent activity cliff partner and found to possess 60 times higher inhibitory activity against MMP-1 than the structurally related compound 3. Furthermore, ph...
Saved in:
| Published in: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2020
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7477548/ https://ncbi.nlm.nih.gov/pubmed/32895466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71696-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|