A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) consists of (1 → 6)-2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, O-acetylated at position C3 or C4. Glycomimetics appear attractive to overcome the CPS intrinsic lability in physiological media, due to cleavag...

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Publicado en:Nat Commun
Main Authors: Enotarpi, Jacopo, Tontini, Marta, Balocchi, Cristiana, van der Es, Daan, Auberger, Ludovic, Balducci, Evita, Carboni, Filippo, Proietti, Daniela, Casini, Daniele, Filippov, Dmitri V., Overkleeft, Hermen S., van der Marel, Gijsbert A., Colombo, Cinzia, Romano, Maria Rosaria, Berti, Francesco, Costantino, Paolo, Codeé, Jeroen D. C., Lay, Luigi, Adamo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477203/
https://ncbi.nlm.nih.gov/pubmed/32895393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18279-x
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