Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality

While genome-wide association studies have identified susceptibility variants for numerous traits, their combined utility for predicting broad measures of health, such as mortality, remains poorly understood. We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and...

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Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Meisner, Allison, Kundu, Prosenjit, Zhang, Yan Dora, Lan, Lauren V., Kim, Sungwon, Ghandwani, Disha, Pal Choudhury, Parichoy, Berndt, Sonja I., Freedman, Neal D., Garcia-Closas, Montserrat, Chatterjee, Nilanjan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477009/
https://ncbi.nlm.nih.gov/pubmed/32758451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.07.002
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