Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality

While genome-wide association studies have identified susceptibility variants for numerous traits, their combined utility for predicting broad measures of health, such as mortality, remains poorly understood. We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Meisner, Allison, Kundu, Prosenjit, Zhang, Yan Dora, Lan, Lauren V., Kim, Sungwon, Ghandwani, Disha, Pal Choudhury, Parichoy, Berndt, Sonja I., Freedman, Neal D., Garcia-Closas, Montserrat, Chatterjee, Nilanjan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477009/
https://ncbi.nlm.nih.gov/pubmed/32758451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.07.002
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