Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer

Non-melanoma skin cancer is the most common form of cancer worldwide. We previously documented an anti-apoptotic role for CDC25A in cutaneous squamous cell carcinoma (SCC), an activity dependent on its association with 14-3-3 proteins. We hypothesized that targeting CDC25A-14-3-3ε interactions may b...

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Vydáno v:Oncotarget
Hlavní autoři: Holmes, Thomas R., Al-Matouq, Jenan, Holmes, Matti, Nicola, Lauren, Rudd, Justin C., Lovas, Sándor, Hansen, Laura A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476737/
https://ncbi.nlm.nih.gov/pubmed/32934772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27700
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