The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a “molecular scissor” that proteolytically cleaves the extracellular region fr...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Koo, Chek Ziu, Harrison, Neale, Noy, Peter J., Szyroka, Justyna, Matthews, Alexandra L., Hsia, Hung-En, Müller, Stephan A., Tüshaus, Johanna, Goulding, Joelle, Willis, Katie, Apicella, Clara, Cragoe, Bethany, Davis, Edward, Keles, Murat, Malinova, Antonia, McFarlane, Thomas A., Morrison, Philip R., Nguyen, Hanh T. H., Sykes, Michael C., Ahmed, Haroon, Di Maio, Alessandro, Seipold, Lisa, Saftig, Paul, Cull, Eleanor, Pliotas, Christos, Rubinstein, Eric, Poulter, Natalie S., Briddon, Stephen J., Holliday, Nicholas D., Lichtenthaler, Stefan F., Tomlinson, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476718/
https://ncbi.nlm.nih.gov/pubmed/32111735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012601
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