Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice

In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV) dysfunction. Here, we aimed to evaluate the effects of CatA...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Hohl, Mathias, Mayr, Manuel, Lang, Lisa, Nickel, Alexander G., Barallobre-Barreiro, Javier, Yin, Xiaoke, Speer, Thimoteus, Selejan, Simina-Ramona, Goettsch, Claudia, Erb, Katharina, Fecher-Trost, Claudia, Reil, Jan-Christian, Linz, Benedikt, Ruf, Sven, Hübschle, Thomas, Maack, Christoph, Böhm, Michael, Sadowski, Thorsten, Linz, Dominik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476717/
https://ncbi.nlm.nih.gov/pubmed/32647007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013488
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