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Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock
INTRODUCTION: Stimulation of beta(2)-adrenergic receptors (β(2)-ARs) inhibits tumor necrosis factor-alpha (TNF-α) release in monocytes. In septic shock, endogenous catecholamines induce β(2)-AR downregulation, leading to an increased TNF-α release. The aims of this study were to analyze the molecula...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646324/ https://ncbi.nlm.nih.gov/pubmed/19091080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc7158 |
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