Preliminary report of in vitro and in vivo effectiveness of dornase alfa on SARS-CoV-2 infection

Dornase alfa, the recombinant form of the human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount of DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in the highly viscous mucus of cystic fibrosis patients...

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Vydáno v:New Microbes New Infect
Hlavní autoři: Okur, H.K., Yalcin, K., Tastan, C., Demir, S., Yurtsever, B., Karakus, G.S., Kancagi, D.D., Abanuz, S., Seyis, U., Zengin, R., Hemsinlioglu, C., Kara, M., Yildiz, M.E., Deliceo, E., Birgen, N., Pelit, N.B., Cuhadaroglu, C., Kocagoz, A.S., Ovali, E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
First Clinical Case Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476504/
https://ncbi.nlm.nih.gov/pubmed/32922804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nmni.2020.100756
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