Preliminary report of in vitro and in vivo effectiveness of dornase alfa on SARS-CoV-2 infection

Dornase alfa, the recombinant form of the human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount of DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in the highly viscous mucus of cystic fibrosis patients...

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Autori principali: H.K. Okur, K. Yalcin, C. Tastan, S. Demir, B. Yurtsever, G.S. Karakus, D.D. Kancagi, S. Abanuz, U. Seyis, R. Zengin, C. Hemsinlioglu, M. Kara, M.E. Yildiz, E. Deliceo, N. Birgen, N.B. Pelit, C. Cuhadaroglu, A.S. Kocagoz, E. Ovali
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020-09-01
Serie:New Microbes and New Infections
Soggetti:
Coronavirus disease 2019
dornase alfa
NETosis
neutrophil extracellular traps
severe acute respiratory syndrome coronavirus 2
Accesso online:http://www.sciencedirect.com/science/article/pii/S2052297520301086
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