Dual inhibition of BRAF and mTOR in BRAF(V600E)-mutant pediatric, adolescent, and young adult brain tumors

Although BRAF inhibition has demonstrated activity in BRAF(V600)–mutated brain tumors, ultimately these cancers grow resistant to BRAF inhibitor monotherapy. Parallel activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway has been implicated as a mechanism of primary a...

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Bibliografiske detaljer
Udgivet i:Cold Spring Harb Mol Case Stud
Main Authors: Sen, Shiraj, Tanaka, Ryuma, Khatua, Soumen, Zaky, Wafik, Janku, Filip, Penas-Prado, Marta, Weathers, Shiao-Pei, Behrang, Amini, Roszik, Jason, Subbiah, Vivek
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
Fag:
Research Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476413/
https://ncbi.nlm.nih.gov/pubmed/32843426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a005041
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