Dual inhibition of BRAF and mTOR in BRAF(V600E)-mutant pediatric, adolescent, and young adult brain tumors

Although BRAF inhibition has demonstrated activity in BRAF(V600)–mutated brain tumors, ultimately these cancers grow resistant to BRAF inhibitor monotherapy. Parallel activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway has been implicated as a mechanism of primary a...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Mol Case Stud
Main Authors: Sen, Shiraj, Tanaka, Ryuma, Khatua, Soumen, Zaky, Wafik, Janku, Filip, Penas-Prado, Marta, Weathers, Shiao-Pei, Behrang, Amini, Roszik, Jason, Subbiah, Vivek
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476413/
https://ncbi.nlm.nih.gov/pubmed/32843426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a005041
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