SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner. Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer. Nevertheless, the mechanistic details of how...

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Pubblicato in:Cancer Biol Med
Autori principali: Yuan, Yue, Fan, Yanling, Gao, Zicong, Sun, Xuan, Zhang, He, Wang, Zhiyong, Cui, Yanfen, Song, Weijie, Wang, Zhaosong, Zhang, Fei, Niu, Ruifang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Compuscript 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476086/
https://ncbi.nlm.nih.gov/pubmed/32944401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2020.0056
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