The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations

Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets. Here, we show that polyP efficiently inhibits the binding of the envelope spike (S)-protein of the coronavirus SARS-CoV-2, the causative agent of...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Neufurth, Meik, Wang, Xiaohong, Tolba, Emad, Lieberwirth, Ingo, Wang, Shunfeng, Schröder, Heinz C., Müller, Werner E.G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474874/
https://ncbi.nlm.nih.gov/pubmed/32905794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114215
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