Phosphorylated CtIP bridges DNA to promote annealing of broken ends

The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP. The roles of these proteins in nucleolytic DSB resection are well characterized, but their role in bridging the DNA ends for efficient and correct...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Öz, Robin, Howard, Sean M., Sharma, Rajhans, Törnkvist, Hanna, Ceppi, Ilaria, KK, Sriram, Kristiansson, Erik, Cejka, Petr, Westerlund, Fredrik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474685/
https://ncbi.nlm.nih.gov/pubmed/32817418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008645117
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