mRNA adenosine methylase (MTA) deposits m(6)A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana

In Arabidopsis thaliana, the METTL3 homolog, mRNA adenosine methylase (MTA) introduces N(6)-methyladenosine (m(6)A) into various coding and noncoding RNAs of the plant transcriptome. Here, we show that an MTA-deficient mutant (mta) has decreased levels of microRNAs (miRNAs) but accumulates primary m...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Bhat, Susheel Sagar, Bielewicz, Dawid, Gulanicz, Tomasz, Bodi, Zsuzsanna, Yu, Xiang, Anderson, Stephen J., Szewc, Lukasz, Bajczyk, Mateusz, Dolata, Jakub, Grzelak, Natalia, Smolinski, Dariusz J., Gregory, Brian D., Fray, Rupert G., Jarmolowski, Artur, Szweykowska-Kulinska, Zofia
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474595/
https://ncbi.nlm.nih.gov/pubmed/32817553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003733117
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