mRNA adenosine methylase (MTA) deposits m(6)A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana

In Arabidopsis thaliana, the METTL3 homolog, mRNA adenosine methylase (MTA) introduces N(6)-methyladenosine (m(6)A) into various coding and noncoding RNAs of the plant transcriptome. Here, we show that an MTA-deficient mutant (mta) has decreased levels of microRNAs (miRNAs) but accumulates primary m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bhat, Susheel Sagar, Bielewicz, Dawid, Gulanicz, Tomasz, Bodi, Zsuzsanna, Yu, Xiang, Anderson, Stephen J., Szewc, Lukasz, Bajczyk, Mateusz, Dolata, Jakub, Grzelak, Natalia, Smolinski, Dariusz J., Gregory, Brian D., Fray, Rupert G., Jarmolowski, Artur, Szweykowska-Kulinska, Zofia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474595/
https://ncbi.nlm.nih.gov/pubmed/32817553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003733117
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